Creatine Supplements – Who benefits most? Does it work? Is it safe? Everything you need to know!

Creatine Supplements – Who benefits most? Does it work? Is it safe? Everything you need to know!

How to certify your supplement:
https://sport.wetestyoutrust.com
https://www.nsfsport.com

REFERENCES:
Dempsey RL, Mazzone MF, Meurer LN. Does oral creatine supplementation improve strength? A meta-analysis.
J Fam Pract
.2002;51(11):945-951.
[PubMed 12485548]

Creatine.
Lexi-Interact
. UpToDate Lexidrug. Waltham, MA: UpToDate, Inc. Accessed October 10, 2024.
https://online.lexi.com/lco/action/interact

Dos Santos EEP, de Araújo RC, Candow DG, et al. Efficacy of creatine supplementation combined with resistance training onmuscle strength and muscle mass in older females: A systematic review and meta-analysis.
Nutrients
. 2021;13(11):3757.doi:10.3390/nu13113757
[PubMed 34836013]

https://www.dynamed.com/management/supplements-for-performance-enhancement-in-sport#GUID-948C30B0-A1E1-4FFE-893D-A3D64AAC9B93

https://www.uptodate.com/contents/nutritional-and-non-medication-supplements-permitted-for-performance-enhancement?search=creatine%20supplement&source=search_result&selectedTitle=1%7E27&usage_type=default&display_rank=1

MUSIC:
Happy Alley by Kevin MacLeod is licensed under a Creative Commons Attribution 4.0 license. https://creativecommons.org/licenses/by/4.0/

50 Comments

  1. @CharlesONeill-i9u on July 27, 2025 at 5:35 am

    Gummy s do not work.

  2. @willdajarrett1107 on July 27, 2025 at 5:37 am

    This was an informative video. Thank you. There is a brand called Athlean that is certified by NSF Sports.

  3. @dlcanaly6518 on July 27, 2025 at 5:38 am

    Thorne

  4. @cleanqueen75 on July 27, 2025 at 5:41 am

    I have kidney disease. Creatine is bad on your kidneys.

  5. @sleepy670 on July 27, 2025 at 5:42 am

    What about those 36-65?

  6. @maxheadroom583 on July 27, 2025 at 5:45 am

    I’m 62, creatine is awesome 👌

  7. @jimmycozzycostine8137 on July 27, 2025 at 5:46 am

    Creatine is good for your energy levels but is more effective if taken with a medium-sized meal, do not take it on an empty stomach, suggest a low 5gr measure to start with if you are just starting for the first time, 👍

  8. @karenlowe3949 on July 27, 2025 at 5:46 am

    I start creatitine and I am having wonderful results. I am 65 years old. I am doing 5 g twice a day right now. Starting out. It has helped with my Brain fog. It has given me endurance. I can tell the difference in my dopamine. Just an overall feel good And able to actually do squats deeper This week Which I have never been able to do. Good morning Barbara. I say if you’re on the fence try it!
    I use the powder form at Costco’s. Can’t remember the name. Think it starts with an R.

  9. @mediocreman6323 on July 27, 2025 at 5:46 am

    4:29 – “Supplements are not regulated, they can pretty much say whatever they want” – laughter from across the ocean in the European Union…

  10. @lgroves336 on July 27, 2025 at 5:47 am

    Do a search on YT for the following video. 3rd party testing of creatine to see if your product is REAL or FAKE. You will be surprised.
    ZERO CREATINE! We Tested Major Creatine Brands, This is What We Found

  11. @Andreas_B. on July 27, 2025 at 5:50 am

    Sorry but all Humans are benifit big time, cuz the long looooong-standing medical belief that humans absorb sufficient creatine rates with normal eating habits (this "normal" has changed several times over the last 100 years) is fundamentally wrong. The conclusions drawn from the famous "double-blind studies regarding creatine intake of 5g daily in vegetarians, vegans, and the elderly" are also based on this medical misconception and are therefore inherently misinterpreted! The "Homo Erectus" during the Pleistocene (2,588 million years ago to 11,650 years ago) were "the first hominin species to use fire; the first to use hunting as an essential element to secure their food supply; the first to be able to walk like a modern human." From Homo erectus, Homo heidelbergensis and Neanderthals (in Eurasia), as well as Homo sapiens (in Africa), and presumably Homo floresiensis (in East Asia) evolved independently of one another. The significant difference from other Homo species and all other mammals, which also have a muscular skeleton and endogenous liver creatine production for normal body and organ function, is that Homo erectus used fire as a technological refinement to transform difficult-to-digest, and thus only edible in tiny quantities, raw meat into easily digestible and highly energetic food. This enabled a predictable food economy and thus more social opportunities than simply ensuring survival. The continued physical and cognitive development of the human brain is based on a diet with large quantities of "roasted meat" – Homo erectus consumed 1-2 kg per meal = 7-14 g of creatine (as well as all other important components such as B vitamins, cholesterol, and fat for energy metabolism and the nervous system) – compared to all other living beings on Earth, which, despite "endogenous creatine production" essentially continue to simply pursue the reproductive maintenance of the species.

    One should assume that even in modern humans the "endogenous creatine production for normal organ and body function" is not sufficient to "adequately supply" the Brain. Cause unlike the Homo erectus, humans today have to deal with a significantly higher volume of information processing combined with a significantly reduced meat diet, thus resulting in a culturally domesticated creatine deficiency. Thus, creatine supplementation in the studies did not in itself produce an "increase in brain performance" but merely restored a naturally normal level of Brain performance. It has also been proven that the "creatine transporter" also transports the VMAT2 protein, which in turn serves to transport monoamines such as noradrenaline, adrenaline, dopamine, and serotonin into the vesicles. It is essential for the storage and subsequent release of these neurotransmitters. When dopamine is released in dopaminergic neurons, their packaging with VMAT2 is essential to prevent possible cell damage from oxidized dopamine during oxidative stress. Disturbances in VMAT2 function can lead to neurodegenerative diseases such as Parkinson’s disease or Huntington’s disease, making VMAT2 an important target for drugs that affect neurotransmitters, such as those used in the treatment of Huntington’s disease or tardive dyskinesia. Due to its close association with insulin production in islet cells, VMAT2 is a suitable target for diabetes diagnosis, and it has been shown that diabetics who take creatine have significantly better and more stable blood sugar levels. That opens up the possibility that Diabetics is a following disease to creatine deficiency. Put very simply, creatine is the powerhouse of a cell, and D-glucose is its fuel. Read more at kreasup dot ch!

    best regards

  12. @VicMorrowind on July 27, 2025 at 5:50 am

    who benefits most ? ? ?
    the manufactures and retailers selling all these suppliments

  13. @dlcanaly6518 on July 27, 2025 at 5:51 am

    Very simple get third-party testing assurance that’s the only way I buy a supplement nowadays, and I don’t buy it off of Amazon because of the possibility of fakes

  14. @industrialexitstrategist2022 on July 27, 2025 at 5:53 am

    1st time viewer new subscriber. Thank you so much for sharing your knowledge.

  15. @zone4garlicfarm on July 27, 2025 at 5:54 am

    Who benefits most from creatine supplements? The same people who benefit from any other supplement. The people who sell supplements.

  16. @g.fortin3228 on July 27, 2025 at 5:54 am

    Nice insight.. Thank you !

  17. @Ciny-f2o on July 27, 2025 at 5:54 am

    What if you have hypothyroidism?

  18. @GrumpyGrandpa-s8d on July 27, 2025 at 5:54 am

    Pre creatine my GFR was 60. Post creatine it went to 66.

  19. @toastedaudiolab on July 27, 2025 at 5:55 am

    Can you elaborate on "take with a protein and a carb"?

  20. @ChristyRisingerMD on July 27, 2025 at 5:56 am

    What do you all think about my new intro? It took me a long time to make it! I am still a newbie on Final Cut Pro – I hope you like it!

  21. @SunShineLady-d4r on July 27, 2025 at 5:56 am

    Creatine made me bloated, constipated and fat 😊 Sorry NOT FOR ME.

  22. @dans9228 on July 27, 2025 at 5:56 am

    Great information, right to the point and all the data was shared in a short period of time.
    Interesting to know about the two certifications. Amazon has ON listed as an NSF certified but it not. Thank you!

  23. @rusty9045 on July 27, 2025 at 6:00 am

    I have also seen a scientific paper that mentions improvements in patients experiencing heart failure when taking creatine. Note that when reviewing the use of creatine it was just in one scientific paper that I happened to find. I didn’t follow it up and look for others. Interesting and sort of makes sense considering the heart is basically a dumb muscle.

  24. @Hemkyns-iw1dt on July 27, 2025 at 6:00 am

    It’s really awesome to hear from someone who’s clearly impartial and not just promoting the sale of a brand!!

  25. @Juangaba on July 27, 2025 at 6:04 am

    65 been taking creatine on and off for decades. Last several years I have been very consistent, about to retire, folks ask me why? I tell them I’m going out on age, they are taken aback when I tell them I’m 65, several major surgeries. They ask about my diet, I don’t diet never have, I eat clean, extremely rare I eat anything out of a box. My work outs are intense, I use a Total Gym Fit Ultimate and add weights. My body fat is much higher than I like, but I feel great and test out 15-20 years my junior. Last colonoscopy Dr. seemed shocked and kept telling me how healthy I am🤷🏻‍♂️. It was very nice but felt very weird, his demeanor. Point is the creatine has made a huge impact not only physically but mentally. My job is very demanding Operations Risk Management, deal with losses cradle to grave, mitigation, demolition, put back and management of the insurance claim, plus multiple additional duties and small projects, directly supervise 8 employees. Grandfather 6 grandkids ( joy of my life) married 47 years together 50.
    I am a strong proponent of healthy living creatine is one of the key gods in my daily regiment.

  26. @TJGriggs25 on July 27, 2025 at 6:07 am

    Best to steer clear of those fake gummies.

  27. @dlcanaly6518 on July 27, 2025 at 6:08 am

    There may be no harm to the kidneys, but your creatinine level will be through the roof and your Dr’s gonna panic and he’s gonna want to send you to a nephrologist. It’s gonna cost a few money in time and stress believe me we’ve been through this.

  28. @barrymantei7795 on July 27, 2025 at 6:08 am

    It’s not necessary to do the loading phase.

  29. @loisrossi841 on July 27, 2025 at 6:10 am

    Thank you.

  30. @soflobootypirate on July 27, 2025 at 6:12 am

    I take 5 grams before a workout with Citrulene and Arginine, and I can feel the enhanced performance and endurance. I can train longer and harder. Have been using it for 30 years. It will make you retain water so you have to sweat a lot of you will bloat.

  31. @rawheadrex on July 27, 2025 at 6:13 am

    Well why did I get these symptoms ? It was awful , eventually after 2 weeks I was literally lying half awake all night. Its a shame because in the day I found it made me really energised , but when I wanted to go to bed I was still wide awake .

  32. @rugershooter5268 on July 27, 2025 at 6:14 am

    At first it diminished my performance, probably not drinking enough water. Then because my muscles are retaining more water they can work harder longer

    There is perceived muscle mass gains because of the water retention in your muscles, quit taking creatine and those "gains" go away, keep working out and you will have actual muscle gain

  33. @yazminmojica4458 on July 27, 2025 at 6:16 am

    👍💯 Thank you 🇲🇽

  34. @larryusagmail4751 on July 27, 2025 at 6:16 am

    Doctors have no training in nutrition or supplements

  35. @markweiss2307 on July 27, 2025 at 6:17 am

    Gummies are a no no ,most have no creatine at all, do your due diligence first!!!

  36. @williamralph9008 on July 27, 2025 at 6:18 am

    For older adults increase in cognitive function is achieved with doses > 20g/day( see Ben Bikman’s talk for references)

  37. @chrisfinn4172 on July 27, 2025 at 6:18 am

    I used to use creatine but one of my regular medications damaged my kidneys. I’ve stopped the medication and changed to a new one. Blood tests say that my kidneys have repaired themselves. Am I ok to try creatine now ?

  38. @dejapoo5508 on July 27, 2025 at 6:18 am

    Clear + concise.

  39. @palitalovelock9888 on July 27, 2025 at 6:21 am

    Who checks if this in fact is creatine in the jar?

  40. @davidcoomber4050 on July 27, 2025 at 6:21 am

    When ever you see someone wearing a white coat they are selling you something, in my experience the people who benefit most from creatine are those selling it , if you think something is doing you good it’s doing you good but don’t kid yourself it’s all in the mind. Never look for health advice on sites like YouTube, look at the real medical data there is a lot of real facts about the effects of this supplement they don’t want you to know like if you eat beef steak four times a week your body will get all the Creatine it needs

  41. @theworshipsinger on July 27, 2025 at 6:22 am

    Dosage?

  42. @kma3647 on July 27, 2025 at 6:22 am

    I very much appreciate the short-form literature review on this. As a pharmacist, I naturally get a lot of questions about supplements. What are they good for? Do they actually work? Are they safe? Are there medical conditions or other medicines they interact with or that we should worry about? etc. This answered those questions quickly and clearly. Thank you!

  43. @capwlf on July 27, 2025 at 6:25 am

    Wow what a great health professional, very good Wife, Mom and researcher for sure! Thank you for sharing with so many all that you have literally brought to the table of nutritional wellbeing.

  44. @fredswartley9778 on July 27, 2025 at 6:26 am

    Does creatine help with chronic fatigue syndrome?

  45. @lisahilton9616 on July 27, 2025 at 6:32 am

    Thank you so much! Extremely helpful!❤

  46. @neilmeiskey5482 on July 27, 2025 at 6:32 am

    Love the upfront honesty. Do those two organizations do all types of supplements or just sorts related? Thanks.

  47. @sopnanak6606 on July 27, 2025 at 6:32 am

    some recent research suggests creatine may promote endometriosis progression. I wonder if some women had negative experience while taking creatine?

  48. @BobbySanders-bf2fr on July 27, 2025 at 6:34 am

    Thanks God……

  49. @CH-iy4go on July 27, 2025 at 6:34 am

    Thorne creatine is NSF certified.

  50. @kbuchanan2026 on July 27, 2025 at 6:34 am

    Creatine can exacerbate any symptoms of overactive bladder and urge frequency. This is not good for every body. Funny, they keep hyping this for dementia in elderly when they are most likely to bladder problems and incontinence which will be made worse by creatine.

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